Hepatitis and Interferon

Hepatitis is a viral disease that remains in the body for longer durations and even lifetime, depending upon the viral genotype.  It exists as Hepatitis A, B, C, D, E, G and H. Hepatitis B and C are treated by interferon at variant doses in every individual. There is a slight chance from recovery from Hepatitis B but it has a vaccine. Hepatitis C is treatable yet chances of recurrence are strong because it does not have a vaccine.

Interferon has a binding affinity with the cellular proteins that in turns kills the viruses despite of their various shapes which may not be identified otherwise. The Pharmacokinetics and Pharmacodynamics of Interferon was studied with and without combination of ribavirin, administered between the range of 800g – 1400g thrice a week or daily. Sustained Virologic Response (SVR) and Rapid Virologic Response (RVR) exposure- response were modeled using logistic regression. The author of the article Population Pharmacokinetics and Pharmacodynamics of Albinterferon Alfa-2b in Patients Treated for Hepatitis C Virus Genotype 2/3 has detailed review on the genotype research and a comparison of efficacy of combined or individual regimens.

Also, Bentham Science Publishers has much more details on the viral hepatitis topics in their open access journals.

The Impact Of Sleep Apnea On Human Health:

Majority of people experience snoring issues while sleeping. In some cases, it can occur due to nasal blockages which result into oral grunts and groans. Similarly, some people suffer from breathing impairments or occasional exchange of gases during sleep. This is known as Sleep Apnea. "Sleep apnea is a common disease that has a powerful impact on public health because it greatly increases the risk of strokes, cancers and mortality from any cause," said lead author Nathaniel S. Marshall, PhD, senior lecturer in clinical trials at the University of Sydney in Australia.

“Sleep Apnea is a common diseasethat has a powerful impact on public health because it greatly increases therisk of strokes, cancers and mortality from any cause.” (Nathaniel S. Marshall, PhD, Senior Lecturer in Clinical Trials at the University of Sydney, Australia)

"Sleep apnea is a common disease that has a powerful impact on public health because it greatly increases the risk of strokes, cancers and mortality from any cause," said lead author Nathaniel S. Marshall, PhD, senior lecturer in clinical trials at the University of Sydney in Australia."Sleep apnea is a common disease that has a powerful impact on public health because it greatly increases the risk of strokes, cancers and mortality from any cause," said lead author Nathaniel S. Marshall, PhD, senior lecturer in clinical trials at the University of Sydney in Australia."Sleep apnea is a common disease that has a powerful impact on public health because it greatly increases the risk of strokes, cancers and mortality from any cause," said lead author Nathaniel S. Marshall, PhD, senior lecturer in clinical trials at the University of Sydney in Australia."Sleep apnea is a common disease that has a powerful impact on public health because it greatly increases the risk of strokes, cancers and mortality from any cause," said lead author Nathaniel S. Marshall, PhD, senior lecturer in clinical trials at the University of Sydney in Australia.Sleep Apnea can be classified into three types:

Ø  Obstructive Sleep Apnea (OSA)

Ø  Central Sleep Apnea (CSA)

Ø  Complex Sleep Apnea (Amalgamation of the above two)

The OSA can take place due to a physical obstruction in the respiratory tract, whereas, the main cause of CSA is the lack of respiratory effort. The combination of both of them is reported in a limited number of cases.

Despite of the fact that Sleep Apnea can happen to any age group or gender, this condition is more common in females. One of the Bentham Science Publishers articles “Influence of Gender on C-Reactive Protein, Fibrinogen, and Erythrocyte Sedimentation Rate in Obstructive Sleep Apnea.” covers all the details related to protein bindings with fibrinogens and erythrocytes sedimentation rates. This research also provides ample information explaining the systemic inflammatory markers relating it with female physiological activity which supports OSA more in females than males.